Cancer cells engineered with CRISPR slay their own kin


gene-edited cancer cells
ON THE OFFENSIVE Gene-edited cancer cells (green) release a protein deadly to other tumor cells (red).

Using gene editing, scientists have hoodwinked tumor cells into turning against their own kind.

Cancer cells circulating in the bloodstream have something of a homing instinct, able to find and return to the tumor where they originated. To capitalize on that ability, researchers engineered these roving tumor cells to secrete a protein that triggers a death switch in resident tumor cells they encounter. The cancer-fighting cancer cells also have a built-in suicide switch — so the weaponized cells self-destruct before they can start tumors of their own, the team reports in the July 11 Science Translational Medicine.

The new study isn’t the first attempt to fight cancer with cancer. Previous research has used circulating tumor cells to deliver cancer-killing viruses to noncirculating tumor cells, for example. But the new approach uses a gene-editing technology called CRISPR/Cas9 to manipulate the offensive-line cancer cells and give them more sophisticated properties, such as the ability to self-destruct once no longer needed.

When circulating tumor cells (green) that are engineered with CRISPR to kill other tumor cells are injected into a mouse, they migrate over time to established tumor cells (red), as seen in these fluorescence photomicrographs.

C. Reinshagen et al/Science Translational Medicine 2018

“The…

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