Tourette syndrome is a brain dysfunction that leads to involuntary motor tics, such as sniffing, blinking, or clapping. In about 10 percent of cases, it also leads to the spontaneous utterance of taboo words or phrases, known as coprolalia. Until recently, these tics were believed to be the result of a dysfunction primarily in a brain structure known as the basal ganglia—a brain region associated with voluntary motor control, which primarily uses the neurotransmitter gamma-aminobutyric acid (GABA) to function. Recent studies of rat, monkey, and even human brains, however, has suggested that the tics stem from a more complex, system-level dysfunction that involves the cerebellum, the thalamus, and the cortex, which are all connected.
To better explore these brain regions and their influence on Tourette syndrome, Daniele Caligiore, a researcher at the Institute of Cognitive Sciences and Technologies of the Italian National Research Council in Italy, and his colleagues created a computer-simulated model of the neural activity of a brain with Tourette syndrome. The results are published in PLOS Computational Biology.
“The model presented here is a first step of a research agenda aiming at building virtual patients, allowing us to test potential therapies by using computer simulations,” Caligiore tells mental_floss. This method can be performed at low cost, without ethical implications, and, he hopes, help develop “more effective therapeutic protocols, and suggest promising therapeutic interventions.”
If the idea of physicalism is correct — that all of our mental states can be described in purely physical terms — then neuroscience is not only the study of our brains, but the study of our entire existence. Neuroengineering, defined as the application of engineering principles to neurological problems, then becomes how we engineer our relationship with existence itself.
Fifty years ago, nobody but computer programmers knew the personal computer was being developed, and the primary market for the device was thought to be scientists. Today, computers are a ubiquitous.
Digital technology has revolutionized nearly every facet of our lives. Today, neuroengineering is in a similar infancy. While most people would understand the basic idea of using engineering techniques to alter, improve, repair, and study neural systems, most people would lack for ideas on the application.
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Brain Science: Optogenetics and Expansion Microscopy
MIT Professor, Media Lab Synthetic Neurobiology Group Leader
As professor of Biological Engineering and Brain and Cognitive Sciences at the MIT Media Lab, Boyden has launched an award-winning series of classes at MIT which teach principles of neural engineering, starting with the basic principles of how to control and observe neural functions. While studying neuroscience at Stanford University as a Hertz Foundation Fellow, Boyden discovered that human memories are stored by a specific molecular mechanism, and that the content of a memory determines the mechanism used by the brain.
His work focuses on dramatically improving how the brain is imaged, opening a world of opportunities for people who wish to study the neural pathways that make our brains work. Dr. Boyden’s high resolution 3-D maps of the brain, unlike prior 2-D maps, allow researchers to pinpoint exactly what part of the brain they wish to…